The cuts are the latest in a series by airlines in the United States to ease air traffic disruptions this summer.
United Airlines cut its schedule by 12% this summer at Newark Liberty International Airport, which has been plagued by cancellations and delays. Delta Air Lines also "strategically decreased" flights this summer.
Air traffic disruptions have been bad in Europe, too. London Heathrow and Amsterdam Schiphol airports announced moves this week to curb congestion.
On Wednesday, the US Transportation Security Administration screened more than 2.1 million passengers at airport security checkpoints nationwide, 86% of the same day in 2019.
American says schedule adjustments have been made "with goal of moving customers to different flights."
The airline says it will contact passengers directly with "alternative travel options that get them to their destinations" with customers able to seek a full refund if the new options won't work for them.
On Wednesday, the US Department of Transportation proposed a rule that would expand the circumstances when airline passengers can get refunds.
That proposal comes amid a flood of complaints from passengers seeking refunds from airlines since the outset of the pandemic.